A KAUST-led research team has observed intergenerational epigenetic inheritance in corals, demonstrating that corals pass patterns of DNA to their offspring. The research, published in Nature Climate Change, shows that corals can adapt to environmental changes and pass those traits on through DNA methylation patterns. This is the first time this process has been observed in animals, previously only seen in plants. Why it matters: This finding could enable biologists to train corals in nurseries to produce offspring better equipped to survive changing marine environments, aiding coral reef restoration efforts.
The paper introduces a benchmark of 1,000 multiple-choice questions to evaluate LLMs on Islamic inheritance law ('ilm al-mawarith). Seven LLMs were tested, with o3 and Gemini 2.5 achieving over 90% accuracy, while ALLaM, Fanar, LLaMA, and Mistral scored below 50%. Error analysis revealed limitations in handling structured legal reasoning. Why it matters: This research highlights the challenges and opportunities for adapting LLMs to complex, culturally-specific legal domains like Islamic jurisprudence.
A KAUST team developed piRNAi, a gene-silencing tool in nematode worms using synthetic RNA sequences interacting with the piRNA pathway. They successfully silenced genes involved in sex determination and other functions, demonstrating multiplexed gene silencing. The gene silencing lasted for varying durations across generations, up to six generations. Why it matters: This expands the molecular toolkit for gene manipulation and offers potential therapeutic applications in humans, given the presence of the same gene-silencing pathway.
KAUST researchers have developed a genomic resource for Tausch’s goatgrass (Aegilops tauschii), a wild relative of wheat, by creating 46 high-quality genome assemblies. They compiled 493 genetically distinct accessions from an initial 900, collaborating with the Open Wild Wheat Consortium to select accessions with traits of interest, such as disease resistance and stress tolerance. Screening these assemblies helped identify rust resistance genes, including mapping a stem rust resistance gene to the Sr33 locus. Why it matters: This genomic resource will accelerate gene discovery in wheat, potentially improving modern wheat varieties and enhancing global food security.
A partner at Oblon, Stefan Uwe Koschmieder, explained key points for patenting software and AI inventions. Koschmieder works with GCC universities on IP programs and advises foreign clients on IP portfolio management. He also lectured at Freie Universität Berlin on Intellectual Property. Why it matters: As software and AI innovation grows in the GCC, understanding patent law is increasingly important for protecting intellectual property and fostering local innovation.