A KAUST team developed piRNAi, a gene-silencing tool in nematode worms using synthetic RNA sequences interacting with the piRNA pathway. They successfully silenced genes involved in sex determination and other functions, demonstrating multiplexed gene silencing. The gene silencing lasted for varying durations across generations, up to six generations. Why it matters: This expands the molecular toolkit for gene manipulation and offers potential therapeutic applications in humans, given the presence of the same gene-silencing pathway.
KAUST's Environmental Epigenetics Program (KEEP), led by Prof. Valerio Orlando, focuses on understanding how cells acquire and maintain memory, particularly in response to environmental factors. The research investigates the role of non-coding RNA and chromosomal components in regulating gene expression beyond the DNA sequence. Epigenetics explains how the same genome can be interpreted differently, allowing cells and organs to adapt to changing conditions. Why it matters: This research could provide insights into how environmental factors impact gene expression and cell function, potentially leading to advances in understanding and treating diseases.
A KAUST-led research team has observed intergenerational epigenetic inheritance in corals, demonstrating that corals pass patterns of DNA to their offspring. The research, published in Nature Climate Change, shows that corals can adapt to environmental changes and pass those traits on through DNA methylation patterns. This is the first time this process has been observed in animals, previously only seen in plants. Why it matters: This finding could enable biologists to train corals in nurseries to produce offspring better equipped to survive changing marine environments, aiding coral reef restoration efforts.
KAUST researchers reported the full genome sequencing of einkorn wheat in Nature. A new 'cooling score' metric was created to study heat's impact on solar cell performance. KAUST is also optimizing MXenes for lithium batteries and using biomimetic mineralization for smart agriculture. Why it matters: This research demonstrates KAUST's contributions to diverse fields, including genomics, sustainable energy, and smart agriculture, advancing technological innovation in Saudi Arabia.
KAUST Discovery Professor Aranda's team has been researching coral adaptation to temperature and ocean acidification. The research is focused on the transgenerational aspect of this adaptation using controlled environments. The research has been ongoing for the past two years. Why it matters: Understanding the epigenetic mechanisms of climate resilience in corals is crucial for conservation efforts in the Red Sea and beyond.