KAUST researchers are exploring the link between nutrition and brain-energy metabolism to address cognitive decline, dementia, and Alzheimer’s disease. Dr. Pierre Magistretti and Dr. Johannes le Coutre are collaborating on ways to merge brain-energy metabolism research into the field of nutrition. They published an article entitled “Goals in Nutrition Science 2015-2020” in the journal Frontiers in Nutrition. Why it matters: This research could lead to nutritional interventions to hinder or prevent cognitive decline, offering a new approach beyond traditional drug treatments.
Dr. Paolo Sassone-Corsi from UC Irvine spoke at KAUST's 2019 Winter Enrichment Program about circadian rhythms. He discussed how modern lifestyles disrupt our internal clocks, impacting our health and metabolism. Studies show that the timing of food intake affects weight gain, with eating late at night causing metabolic stress. Why it matters: This highlights the importance of circadian rhythm research for understanding and mitigating the health consequences of modern lifestyles in the region.
Nate Hagens from the University of Minnesota spoke at KAUST's Winter Enrichment Program (WEP) 2018 about the intersection of energy, human behavior, and economics. Hagens argued that society functions as an energy-dissipating "superorganism," with human preferences correlated with increasing energy needs. He emphasized that energy, not money, is the real capital, but global society is running out of it. Why it matters: The talk highlights the importance of viewing society through an ecological lens, particularly in the context of the GCC region's reliance on energy resources.
KAUST and the Center for Epigenetics and Metabolism (CEM) at UC Irvine have formed a partnership to advance epigenetics research, focusing on the interplay between genes and metabolism. The collaboration involves researchers from both institutions, including Professors Valerio Orlando and Pierre J. Magistretti from KAUST, and Professors Paolo Sassone-Corsi and Emiliana Borrelli from UCI. The partnership will include an exchange program for students, post-doctoral fellows, and sabbatical professors, as well as joint KAUST-UC Irvine conferences. Why it matters: This partnership enhances KAUST's research capabilities in fundamental cellular processes and positions the institution at the forefront of epigenetics research in the region.
KAUST and EPFL Blue Brain Project researchers propose a new theory about a 'secret language' used by cells for internal communication regarding the external world. Using a computational model, they suggest that metabolic pathways can code details about neuromodulators that stimulate energy consumption. The model focuses on astrocytes and their cooperation with neurons in fueling the brain. Why it matters: This suggests a new avenue for understanding information processing in the brain and how cells contribute to the energy efficiency of brains compared to computers.
KAUST hosted the Nature Conferences: Brain Energy Metabolism in Health and Disease, convening experts to discuss brain energy use and its impact on function and disease. Researchers from KAUST and global institutions shared insights on metabolic interactions among brain cells and the brain's role in whole-body energy regulation. KAUST's President Sir Edward Byrne emphasized brain health as essential for the cognitive economy, aligning with Saudi Arabia’s Vision 2030. Why it matters: The conference highlights KAUST's growing role in global neuroscience research and its commitment to addressing critical health challenges through international collaboration.
KAUST Discovery highlights the contributions of Magistretti to the field of neuroenergetics. His research explores the cellular and molecular basis of brain energy metabolism and brain imaging. Magistretti's group discovered mechanisms underlying the coupling between neuronal activity and energy consumption, revealing the role of astrocytes. Why it matters: Understanding brain energy metabolism and the role of glial cells can advance brain imaging techniques and our understanding of neuronal processes.
Juan Carlos Izpisua Belmonte from the Salk Institute discussed aging and regenerative medicine at the KAUST 2019 Winter Enrichment Program. His team is combining gene editing and stem cell technologies to grow rat organs in mice and human cells in pig and cattle embryos. The Salk team is collaborating with KAUST to rejuvenate organs using noncoding RNAs and small metabolites. Why it matters: This research collaboration between KAUST and the Salk Institute explores innovative approaches to address age-related diseases and organ regeneration, with potential long-term impacts on healthcare in the region.