KAUST researchers are exploring the link between nutrition and brain-energy metabolism to address cognitive decline, dementia, and Alzheimer’s disease. Dr. Pierre Magistretti and Dr. Johannes le Coutre are collaborating on ways to merge brain-energy metabolism research into the field of nutrition. They published an article entitled “Goals in Nutrition Science 2015-2020” in the journal Frontiers in Nutrition. Why it matters: This research could lead to nutritional interventions to hinder or prevent cognitive decline, offering a new approach beyond traditional drug treatments.
Dr. Paolo Sassone-Corsi from UC Irvine spoke at KAUST's 2019 Winter Enrichment Program about circadian rhythms. He discussed how modern lifestyles disrupt our internal clocks, impacting our health and metabolism. Studies show that the timing of food intake affects weight gain, with eating late at night causing metabolic stress. Why it matters: This highlights the importance of circadian rhythm research for understanding and mitigating the health consequences of modern lifestyles in the region.
Nate Hagens from the University of Minnesota spoke at KAUST's Winter Enrichment Program (WEP) 2018 about the intersection of energy, human behavior, and economics. Hagens argued that society functions as an energy-dissipating "superorganism," with human preferences correlated with increasing energy needs. He emphasized that energy, not money, is the real capital, but global society is running out of it. Why it matters: The talk highlights the importance of viewing society through an ecological lens, particularly in the context of the GCC region's reliance on energy resources.
KAUST hosted the Nature Conferences: Brain Energy Metabolism in Health and Disease, convening experts to discuss brain energy use and its impact on function and disease. Researchers from KAUST and global institutions shared insights on metabolic interactions among brain cells and the brain's role in whole-body energy regulation. KAUST's President Sir Edward Byrne emphasized brain health as essential for the cognitive economy, aligning with Saudi Arabia’s Vision 2030. Why it matters: The conference highlights KAUST's growing role in global neuroscience research and its commitment to addressing critical health challenges through international collaboration.
KAUST and the Center for Epigenetics and Metabolism (CEM) at UC Irvine have formed a partnership to advance epigenetics research, focusing on the interplay between genes and metabolism. The collaboration involves researchers from both institutions, including Professors Valerio Orlando and Pierre J. Magistretti from KAUST, and Professors Paolo Sassone-Corsi and Emiliana Borrelli from UCI. The partnership will include an exchange program for students, post-doctoral fellows, and sabbatical professors, as well as joint KAUST-UC Irvine conferences. Why it matters: This partnership enhances KAUST's research capabilities in fundamental cellular processes and positions the institution at the forefront of epigenetics research in the region.
A KAUST article discusses the future of energy, highlighting the role of hydrocarbon fuels and the need for sustainable practices. Professor Tadeusz W. Patzek's paper emphasizes finding sustainable bridges until alternative energy sources become viable. The article contrasts optimistic and pessimistic views on energy sustainability, drawing parallels to the whale oil industry. Why it matters: The piece highlights the tension between continued reliance on fossil fuels and the urgent need for alternative energy sources and reduced consumption in the GCC region and globally.
KAUST faculty member Enrico Traversa is researching nanostructured materials for sustainable development in energy, environment, healthcare, and solid oxide fuel cells (SOFCs). His work focuses on developing next-generation SOFCs based on chemically stable proton-conducting electrolytes to reduce operating temperatures. Traversa also develops scaffold biomaterials for tissue regeneration, aiming to create heart tissue using patient-derived stem cells. Why it matters: This research contributes to KAUST's focus on energy, water, environment and food, with potential for advancements in clean energy and regenerative medicine.
KAUST Discovery highlights the contributions of Magistretti to the field of neuroenergetics. His research explores the cellular and molecular basis of brain energy metabolism and brain imaging. Magistretti's group discovered mechanisms underlying the coupling between neuronal activity and energy consumption, revealing the role of astrocytes. Why it matters: Understanding brain energy metabolism and the role of glial cells can advance brain imaging techniques and our understanding of neuronal processes.