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Scientists uncover how brain support cells influence memory

KAUST ·

Scientists at King Abdullah University of Science and Technology (KAUST) have discovered that astrocytes, a type of non-neuronal cell, actively influence communication between neurons and processes linked to learning and memory. Their study, published in The Journal of Physiology, revealed that lactate not only provides energy to neurons but also triggers a signaling pathway within them, challenging the traditional view of astrocytes as passive support cells. This research, conducted largely at KAUST with international collaboration from Italy and Switzerland, provides new insights into the molecular mechanisms supporting brain cell communication and synaptic plasticity. Why it matters: These findings are significant for understanding fundamental brain science and could open new avenues for therapeutic strategies targeting neurological disorders and memory loss.

KAUST researcher Corrado Calì awarded at Italian neuroscience conference

KAUST ·

KAUST researcher Corrado Calì won an award at the Brainstorming Research Assembly for Young Neuroscientists (BraYn) in Italy for his work on glycogen modulation and synapse stabilization. Calì presented research in collaboration with KAUST Professor Andrea Falqui and Dr. Elena Vezzoli from the University of Milan, investigating the lactate shuttle's involvement in synaptic plasticity. Calì and KAUST colleagues are also collaborating with the Blue Brain Project to produce a computer simulation of astrocyte-neuron coupling, using 3D virtual reality to investigate brain cell morphologies at the nanoscale. Why it matters: This award recognizes KAUST's contribution to neuroscience research and highlights the university's collaborative efforts in understanding brain plasticity and developing advanced tools for studying brain structures.