KAUST researchers collaborated with the Blue Brain Project to study astrocytes, brain cells crucial for memory and learning. Dr. Corrado Calì produced 3D models of astrocytes using serial block-face electron microscopy to understand their structure. The study, published in Progress in Neurobiology, reveals how lactate transfer from astrocytes to neurons contributes to brain energy usage. Why it matters: Understanding astrocyte function could lead to new drugs for treating conditions like stroke and Alzheimer's disease by improving brain cell function.
Dr. Yves Agid from the ICM Paris Institute of Translational Neuroscience lectured at KAUST's 2018 Winter Enrichment Program about the role of glial cells in brain function and behavior. He highlighted that glial cells, often overlooked in research, are crucial for neural synchronization and overall intelligence. Dysfunction of glial cells can induce pathologies like Alzheimer's and Parkinson's disease. Why it matters: The lecture underscored the importance of studying glial cells in addition to neurons for understanding and treating neurodegenerative disorders, which could influence future research directions at KAUST and in the region.
KAUST and EPFL Blue Brain Project researchers propose a new theory about a 'secret language' used by cells for internal communication regarding the external world. Using a computational model, they suggest that metabolic pathways can code details about neuromodulators that stimulate energy consumption. The model focuses on astrocytes and their cooperation with neurons in fueling the brain. Why it matters: This suggests a new avenue for understanding information processing in the brain and how cells contribute to the energy efficiency of brains compared to computers.
KAUST hosted the Nature Conferences: Brain Energy Metabolism in Health and Disease, convening experts to discuss brain energy use and its impact on function and disease. Researchers from KAUST and global institutions shared insights on metabolic interactions among brain cells and the brain's role in whole-body energy regulation. KAUST's President Sir Edward Byrne emphasized brain health as essential for the cognitive economy, aligning with Saudi Arabia’s Vision 2030. Why it matters: The conference highlights KAUST's growing role in global neuroscience research and its commitment to addressing critical health challenges through international collaboration.
KAUST researcher Corrado Calì won an award at the Brainstorming Research Assembly for Young Neuroscientists (BraYn) in Italy for his work on glycogen modulation and synapse stabilization. Calì presented research in collaboration with KAUST Professor Andrea Falqui and Dr. Elena Vezzoli from the University of Milan, investigating the lactate shuttle's involvement in synaptic plasticity. Calì and KAUST colleagues are also collaborating with the Blue Brain Project to produce a computer simulation of astrocyte-neuron coupling, using 3D virtual reality to investigate brain cell morphologies at the nanoscale. Why it matters: This award recognizes KAUST's contribution to neuroscience research and highlights the university's collaborative efforts in understanding brain plasticity and developing advanced tools for studying brain structures.
MBZUAI researchers are developing spiking neural networks (SNNs) to emulate the energy efficiency of the human brain. Traditional deep learning models like those powering ChatGPT consume significant energy, with a single query using 3.96 watts. SNNs aim to mimic biological neurons more closely to reduce energy consumption, as the human brain uses only a fraction of the energy compared to these models. Why it matters: This research could lead to more sustainable and energy-efficient AI technologies, addressing a major challenge in deploying large-scale AI systems.
KAUST researchers are exploring the link between nutrition and brain-energy metabolism to address cognitive decline, dementia, and Alzheimer’s disease. Dr. Pierre Magistretti and Dr. Johannes le Coutre are collaborating on ways to merge brain-energy metabolism research into the field of nutrition. They published an article entitled “Goals in Nutrition Science 2015-2020” in the journal Frontiers in Nutrition. Why it matters: This research could lead to nutritional interventions to hinder or prevent cognitive decline, offering a new approach beyond traditional drug treatments.
KAUST Discovery highlights the contributions of Magistretti to the field of neuroenergetics. His research explores the cellular and molecular basis of brain energy metabolism and brain imaging. Magistretti's group discovered mechanisms underlying the coupling between neuronal activity and energy consumption, revealing the role of astrocytes. Why it matters: Understanding brain energy metabolism and the role of glial cells can advance brain imaging techniques and our understanding of neuronal processes.