Eva Aylagas Martinez, a postdoctoral fellow at KAUST's Red Sea Research Center (RSRC), studies changes in Red Sea communities using environmental DNA. She first visited KAUST during her Ph.D. as part of a collaboration with a European research project (DEVOTES). Her research is supervised by KAUST Professor Michael Berumen. Why it matters: This highlights KAUST's role in attracting international research talent to study critical environmental issues in the Red Sea, contributing to marine conservation efforts.
A KAUST-led research team has observed intergenerational epigenetic inheritance in corals, demonstrating that corals pass patterns of DNA to their offspring. The research, published in Nature Climate Change, shows that corals can adapt to environmental changes and pass those traits on through DNA methylation patterns. This is the first time this process has been observed in animals, previously only seen in plants. Why it matters: This finding could enable biologists to train corals in nurseries to produce offspring better equipped to survive changing marine environments, aiding coral reef restoration efforts.
A KAUST-led research team is deploying DNA sequencing technology originally used on the International Space Station to analyze DNA samples in extreme environments along the Saudi Red Sea coast. The portable technology enables on-site extraction, concentration, and sequencing of samples from coral reefs and mangrove forests, minimizing DNA deterioration. Preliminary results indicate a more diverse and complex microbiome than previously found. Why it matters: This application of space-based technology to marine conservation in the Red Sea could provide critical insights into how coral reefs and mangroves adapt to climate change, informing preservation and restoration efforts.
KAUST's Environmental Epigenetics Program (KEEP), led by Prof. Valerio Orlando, focuses on understanding how cells acquire and maintain memory, particularly in response to environmental factors. The research investigates the role of non-coding RNA and chromosomal components in regulating gene expression beyond the DNA sequence. Epigenetics explains how the same genome can be interpreted differently, allowing cells and organs to adapt to changing conditions. Why it matters: This research could provide insights into how environmental factors impact gene expression and cell function, potentially leading to advances in understanding and treating diseases.
A KAUST Global Ocean Genome workshop convened international scientists to discuss and evaluate the global ocean genome's progress. Participants assessed the representation of microbial communities and their gene pools, explored the functional capacities of the global ocean microbiome, and examined the distribution of key functional genes. KAUST aims to become a repository of global metagenome data, using big-data systems to explore ocean metagenome knowledge. Why it matters: This initiative highlights KAUST's commitment to advancing microbiome research and fostering international collaboration in marine genomics, positioning the university as a key player in understanding and utilizing ocean biodiversity.
KAUST researchers, in collaboration with Spanish scientists, have released the Global Ocean Gene Catalog 1.0, the world's largest open-source catalog of marine microbes. The catalog, created using the KAUST Metagenomic Analysis Platform (KMAP), matches microbial class with gene function, geographic location, and habitat type, including 317 million unique gene clusters. The catalog analyzes 2102 ocean samples taken from different depths and locations around the world. Why it matters: This resource will enable researchers to investigate ocean ecosystems, track pollution impact, and explore biotechnology applications, potentially driving significant advances in fields like antibiotic discovery and plastic degradation.
KAUST researchers from the Red Sea Research Center (RSRC) and Computational Bioscience Research Center (CBRC) found macroalgae DNA prevalent in the open ocean, up to 5,000 km from coastal areas. 69% of drifting macroalgae sinks below 1,000 m depth, sequestering carbon in deep ocean waters. The study used metagenomes generated by global ocean expeditions Tara Oceans and Malaspina, analyzed via KAUST's DMAP platform and Shaheen supercomputer. Why it matters: The findings confirm the role of macroalgae in carbon sequestration, highlighting their importance in blue carbon assessments for climate change mitigation and underscoring KAUST's contribution to environmental sustainability research.
Eduardo da Veiga Beltrame, bioinformatics lead at ImYoo (a Caltech spinout), presented on scalable methods for single-cell omics data analysis, including kallisto|bustools and scvi-tools. He highlighted their use in ImYoo's decentralized longitudinal study on Inflammatory Bowel Disease (IBD), where patients self-collect capillary blood samples. Beltrame also discussed his research on STEM education programs in Brazil as a visiting scholar at UC Berkeley. Why it matters: This highlights the growing trend of decentralized clinical studies leveraging advanced single-cell technologies for precision medicine, showcasing the potential of remote data collection and analysis in understanding complex diseases.