KAUST's Environmental Epigenetics Program (KEEP), led by Prof. Valerio Orlando, focuses on understanding how cells acquire and maintain memory, particularly in response to environmental factors. The research investigates the role of non-coding RNA and chromosomal components in regulating gene expression beyond the DNA sequence. Epigenetics explains how the same genome can be interpreted differently, allowing cells and organs to adapt to changing conditions. Why it matters: This research could provide insights into how environmental factors impact gene expression and cell function, potentially leading to advances in understanding and treating diseases.
A KAUST-led research team has observed intergenerational epigenetic inheritance in corals, demonstrating that corals pass patterns of DNA to their offspring. The research, published in Nature Climate Change, shows that corals can adapt to environmental changes and pass those traits on through DNA methylation patterns. This is the first time this process has been observed in animals, previously only seen in plants. Why it matters: This finding could enable biologists to train corals in nurseries to produce offspring better equipped to survive changing marine environments, aiding coral reef restoration efforts.
KAUST held an international research conference on environmental epigenetics in 2017. The conference included presentations by Professor Paolo Sassone-Corsi from the University of California, Irvine. Participants also included KAUST Professor Valerio Orlando, Emiliana Borrelli, Ueli Grossniklaus and Juan Carlos Belmonte. Why it matters: KAUST is positioning itself as a research hub for advanced bioscience.
KAUST Discovery Professor Aranda's team has been researching coral adaptation to temperature and ocean acidification. The research is focused on the transgenerational aspect of this adaptation using controlled environments. The research has been ongoing for the past two years. Why it matters: Understanding the epigenetic mechanisms of climate resilience in corals is crucial for conservation efforts in the Red Sea and beyond.
KAUST and the Center for Epigenetics and Metabolism (CEM) at UC Irvine have formed a partnership to advance epigenetics research, focusing on the interplay between genes and metabolism. The collaboration involves researchers from both institutions, including Professors Valerio Orlando and Pierre J. Magistretti from KAUST, and Professors Paolo Sassone-Corsi and Emiliana Borrelli from UCI. The partnership will include an exchange program for students, post-doctoral fellows, and sabbatical professors, as well as joint KAUST-UC Irvine conferences. Why it matters: This partnership enhances KAUST's research capabilities in fundamental cellular processes and positions the institution at the forefront of epigenetics research in the region.