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Scientists uncover how brain support cells influence memory

KAUST ·

Scientists at King Abdullah University of Science and Technology (KAUST) have discovered that astrocytes, a type of non-neuronal cell, actively influence communication between neurons and processes linked to learning and memory. Their study, published in The Journal of Physiology, revealed that lactate not only provides energy to neurons but also triggers a signaling pathway within them, challenging the traditional view of astrocytes as passive support cells. This research, conducted largely at KAUST with international collaboration from Italy and Switzerland, provides new insights into the molecular mechanisms supporting brain cell communication and synaptic plasticity. Why it matters: These findings are significant for understanding fundamental brain science and could open new avenues for therapeutic strategies targeting neurological disorders and memory loss.

KAUST's Vice President of Research presents 2023 Nansen Neuroscience Lecture

KAUST ·

KAUST's Vice President of Research, Professor Pierre Magistretti, presented the 2023 Nansen Neuroscience Lecture in Oslo. The lecture highlighted his discovery of the astrocyte-neuron lactate shuttle and its role in brain physiology and pathology. His research explains how astrocytes feed neurons lactate as a primary energy source, impacting memory and cognition. Why it matters: The lecture recognizes KAUST's contribution to neuroscience and highlights the importance of understanding brain energy consumption for treating neurological disorders.