KAUST researchers are working to improve gene editing tools, specifically CRISPR/Cas9, for crop bioengineering to address food security challenges. Magdy Mahfouz's lab is developing a germline engineering platform to produce gene-edited plants without foreign DNA and bypass time-consuming tissue culture. A recent European court decision classifies CRISPR/Cas9 crops as GMOs, facing stringent regulations, contrasting with the U.S. where CRISPR-edited mushrooms are already available. Why it matters: Advances in gene editing at KAUST could significantly enhance crop yields and stress tolerance in the region, but regulatory hurdles remain a key challenge for deployment.
Dr. John Bedbrook of DiCE Molecules LLC spoke at KAUST about the challenges of feeding a growing population with increasingly stressed arable land. He noted the increasing demand for meat in emerging economies exacerbates the problem. Bedbrook emphasized the role of genetics and hybridization in improving crop yields and quality to address food security. Why it matters: Investments in agricultural biotechnology are crucial for the GCC region to enhance food security and reduce reliance on imports amid changing climate conditions.
Dr. Ingo Potrykus, co-inventor of Golden Rice, discussed the potential of this genetically modified crop to combat vitamin A deficiency at KAUST's 2014 Winter Enrichment Program. Golden Rice, engineered to produce beta carotene, could prevent millions of deaths and cases of blindness annually in developing countries where rice is a staple. Regulatory hurdles for GMOs have stalled the distribution of Golden Rice, increasing development costs and delaying its availability to farmers. Why it matters: This highlights the potential of biotechnology developed and discussed in the GCC to address global health challenges, but also the regulatory and ethical considerations surrounding GMOs.
A KAUST team developed piRNAi, a gene-silencing tool in nematode worms using synthetic RNA sequences interacting with the piRNA pathway. They successfully silenced genes involved in sex determination and other functions, demonstrating multiplexed gene silencing. The gene silencing lasted for varying durations across generations, up to six generations. Why it matters: This expands the molecular toolkit for gene manipulation and offers potential therapeutic applications in humans, given the presence of the same gene-silencing pathway.
KAUST and KFSHRC have developed NanoRanger, a new gene sequencing system for identifying mutations causing genetic diseases. NanoRanger offers a faster and simpler process to detect DNA abnormalities at base resolution, building on existing long-read sequencing technologies. The system is designed to be cheaper and faster, targeting diseases prevalent in Saudi Arabia due to consanguinity. Why it matters: The technology has the potential to improve diagnosis and treatment of Mendelian diseases, which are especially prevalent in the Arab world.
KAUST plant scientists are advocating for the deployment of new plant breeding technologies, including gene editing, to enhance global food security. Researchers Mark Tester and Magdy Mahfouz highlight these methods' potential to improve crops by minimizing crop life cycle for research on breeding, selection, and fixing of useful genes. They argue these technologies offer alternatives to genetically modified crops, potentially lowering regulatory costs and increasing seed affordability for farmers in developing countries. Why it matters: These advancements, coupled with regional seed-sharing initiatives, could significantly boost food production and accessibility in less-developed countries in the Middle East and globally.
J. Carlos Santamarina, a Professor of Earth Science and Engineering at KAUST, is researching geomaterial behavior and subsurface processes. His work focuses on energy geo-engineering, resource recovery, and geological storage of energy waste. He uses particle-level experiments, numerical methods, and monitoring systems to understand coupled thermo-hydro-bio-chemo-mechanically processes. Why it matters: This research contributes to energy sustainability and addresses global energy challenges through advanced geotechnology.
Kyle Lauersen, Assistant Professor of Bioengineering at KAUST, credits his early martial arts training for instilling focus and confidence. He initially pursued education degrees but shifted to molecular biology and genetic engineering after lab experiences. Lauersen's PhD work in Germany involved recoding algal genes for biotechnology. Why it matters: His journey highlights the diverse paths to STEM careers and KAUST's role in attracting international researchers focused on sustainable biotechnology.