Nobel laureate Dr. Michael Young from Rockefeller University presented his research on circadian rhythms at KAUST as part of the 2019 Winter Enrichment Program. His work on Drosophila genes has significantly advanced the understanding of circadian rhythm mechanisms. Young's research identified nine genes that regulate circadian rhythmicity at the molecular level, influencing thousands of gene expression patterns. Why it matters: This highlights KAUST's role in hosting leading international researchers and fostering scientific exchange on fundamental biological processes.
KAUST Discovery Professor Jesper Tegnér collaborated with UK researchers to develop algorithms explaining decision-making in insects and rats. Assoc. Prof. Robert Hoehndorf's lab introduced a tool for identifying genetic variants linked to rare diseases based on patient symptoms. KAUST scientists also studied monkeypox infection of human skin using stem cells and marine microbiome adaptation to thermal changes. Why it matters: These diverse research projects highlight KAUST's contributions to computational biology, virology, and marine science, advancing knowledge with implications for healthcare and environmental challenges.
A KAUST team developed piRNAi, a gene-silencing tool in nematode worms using synthetic RNA sequences interacting with the piRNA pathway. They successfully silenced genes involved in sex determination and other functions, demonstrating multiplexed gene silencing. The gene silencing lasted for varying durations across generations, up to six generations. Why it matters: This expands the molecular toolkit for gene manipulation and offers potential therapeutic applications in humans, given the presence of the same gene-silencing pathway.
Researchers at KAUST and Peking University Third Hospital have created a novel blastoid model for studying early human development using extended pluripotent stem cells (EPSCs). The blastoid is a 3D cell model mimicking the blastocyst phase, avoiding ethical concerns associated with using human embryos. The team showed that blastoids can be cultured to mimic post-implantation development, offering insights into early cell lineages. Why it matters: This innovation provides a way to study human embryogenesis without the ethical constraints of using actual embryos, potentially advancing our understanding of miscarriage and birth defects.
KAUST researchers reported the full genome sequencing of einkorn wheat in Nature. A new 'cooling score' metric was created to study heat's impact on solar cell performance. KAUST is also optimizing MXenes for lithium batteries and using biomimetic mineralization for smart agriculture. Why it matters: This research demonstrates KAUST's contributions to diverse fields, including genomics, sustainable energy, and smart agriculture, advancing technological innovation in Saudi Arabia.
KAUST researchers are using black soldier fly (BSF) larvae to transform organic waste into protein-rich animal feed and high-quality organic fertilizer. BSF larvae consume organic matter and reduce waste volume significantly in a 12-day period. Organic Waste Management Solutions (OWMS), a startup launched by the team, is scaling up and commercializing the BSF-based process. Why it matters: This innovative approach offers a sustainable solution for waste management in the region, generating lower carbon emissions compared to existing technologies like incineration and landfilling.
KAUST researchers are exploring the link between nutrition and brain-energy metabolism to address cognitive decline, dementia, and Alzheimer’s disease. Dr. Pierre Magistretti and Dr. Johannes le Coutre are collaborating on ways to merge brain-energy metabolism research into the field of nutrition. They published an article entitled “Goals in Nutrition Science 2015-2020” in the journal Frontiers in Nutrition. Why it matters: This research could lead to nutritional interventions to hinder or prevent cognitive decline, offering a new approach beyond traditional drug treatments.
KAUST Ph.D. student Sofya Mudrova won the best poster award at the 4th International Congress on Invertebrate Morphology (ICIM4) in Moscow. The poster was in the biology domain. The award recognizes research presented at the conference. Why it matters: Showcases KAUST's strength in attracting and developing talent in interdisciplinary research areas.