KAUST researchers have developed a new synthetic biology process using metabolically engineered algae to produce fragrant sesquiterpenoids, the core compounds in agarwood and other perfumes. The process, developed by the Lauersen and Szekely groups, achieved yields 25 times higher than previous methods and allows for the synthesis of 103 types of fragrant sesquiterpenoids. It also incorporates an energy-efficient nanofiltration step and operates at room temperature with minimal waste. Why it matters: This sustainable bioprocess offers a green alternative to environmentally damaging harvesting of natural resources for the $44 billion fragrance industry, with potential applications in drug development.
KAUST researchers have developed a green synthetic biology approach using engineered algae to replicate the complex fragrances of agarwood, also known as oudh. They catalogued the chemical diversity of sesquiterpenes (STPs) in 58 agarwood samples and reproduced some of the chemical complexity of agarwood STPs in algae using synthetic biology. The team used the green alga Chlamydomonas reinhardtii to produce nine distinct STP chemical products widely found in agarwood, offering a sustainable alternative to harvesting endangered trees. Why it matters: This research provides a sustainable route for producing sought-after fragrances, reducing pressure on endangered agarwood tree populations and promoting green chemistry in the region.
KAUST researchers have developed a technology to convert spoiled dairy and fruit beverages into valuable short-chain and medium-chain carboxylic acids (SCCAs and MCCAs). These acids can be used for animal feed, aviation fuel, and pharmaceuticals, with SCCAs valued at $300 per ton and MCCAs having 10x higher value. A pilot study is underway at KAUST, utilizing over 500 liters of waste per week from regional companies. Why it matters: This innovation supports Saudi Arabia's goal to eliminate 90% of landfill waste by 2040 and promotes a circular economy by transforming food waste into high-value products.
KAUST researchers discovered that the red algae strain Galdieria yellowstonesis can convert sugars from chocolate-processing waste into C-phycocyanin, a valuable blue pigment. The study found that high levels of carbon dioxide promote Galdieria growth, and the resulting phycocyanin was deemed food-safe by the U.S. FDA. Mars supported the research by providing chocolate samples. Why it matters: This research offers a sustainable method for waste management and contributes to a circular economy in the region, with potential applications in food, cosmetics, and pharmaceuticals.
KAUST and Aramco have developed a one-step crude-to-chemicals (C2C) technology that converts crude oil to light olefins in a single-reactor system. The technology, published in Nature Catalysis, aims to maximize the production of materials used in daily life over fuels. Aramco is pursuing growth opportunities in petrochemicals using the C2C method. Why it matters: The C2C breakthrough aligns with Saudi Vision 2030 and could reduce the carbon footprint associated with oil use, creating jobs and supporting a thriving economy.