KAUST faculty member Enrico Traversa is researching nanostructured materials for sustainable development in energy, environment, healthcare, and solid oxide fuel cells (SOFCs). His work focuses on developing next-generation SOFCs based on chemically stable proton-conducting electrolytes to reduce operating temperatures. Traversa also develops scaffold biomaterials for tissue regeneration, aiming to create heart tissue using patient-derived stem cells. Why it matters: This research contributes to KAUST's focus on energy, water, environment and food, with potential for advancements in clean energy and regenerative medicine.
KAUST's Laboratory of Stem Cells and Diseases, led by Assistant Professor Antonio Adamo, uses induced pluripotent stem cells (iPSCs) to model diseases like diabetes. The lab employs a reprogramming technique to revert patient fibroblasts into iPSCs, enabling the study of disease progression in vitro. Adamo's research focuses on enzymes and disregulated transcriptional/epigenetic mechanisms to understand disease onset. Why it matters: This research contributes to regenerative medicine and offers insights into metabolic diseases relevant to the GCC region.
Researchers at KAUST and Peking University Third Hospital have created a novel blastoid model for studying early human development using extended pluripotent stem cells (EPSCs). The blastoid is a 3D cell model mimicking the blastocyst phase, avoiding ethical concerns associated with using human embryos. The team showed that blastoids can be cultured to mimic post-implantation development, offering insights into early cell lineages. Why it matters: This innovation provides a way to study human embryogenesis without the ethical constraints of using actual embryos, potentially advancing our understanding of miscarriage and birth defects.
Juan Carlos Izpisua Belmonte from the Salk Institute discussed aging and regenerative medicine at the KAUST 2019 Winter Enrichment Program. His team is combining gene editing and stem cell technologies to grow rat organs in mice and human cells in pig and cattle embryos. The Salk team is collaborating with KAUST to rejuvenate organs using noncoding RNAs and small metabolites. Why it matters: This research collaboration between KAUST and the Salk Institute explores innovative approaches to address age-related diseases and organ regeneration, with potential long-term impacts on healthcare in the region.
Khaled Alsayegh at the King Abdullah International Medical Research Center is creating a Saudi Stem Cell Donor Registry, with 80,000 potential donors identified. The aim is to identify universal donors, reprogram their cells into induced pluripotent stem (iPS) cells, and create a gene bank for matched tissue transplants. Alsayegh is collaborating with Jesper Tegnér at KAUST to create pacemaker cells using single-cell RNA sequencing. Why it matters: This initiative could revolutionize precision medicine in KSA by providing readily available, matched cells for transplants, reducing the need for patient-specific reprogramming and improving treatment outcomes.
Dr. Laurent A. Lantieri delivered a keynote address at KAUST on April 17, 2017, discussing microsurgical procedures. The address included a brief history of microsurgery. The event took place in the University Auditorium. Why it matters: Such events expose the KAUST community to advances in specialized medical fields and potential research applications.
J. Carlos Santamarina, a Professor of Earth Science and Engineering at KAUST, is researching geomaterial behavior and subsurface processes. His work focuses on energy geo-engineering, resource recovery, and geological storage of energy waste. He uses particle-level experiments, numerical methods, and monitoring systems to understand coupled thermo-hydro-bio-chemo-mechanically processes. Why it matters: This research contributes to energy sustainability and addresses global energy challenges through advanced geotechnology.
KAUST researchers are exploring novel chemical reactors and separation processes using mathematical design, with a focus on time and shape variables to enhance transport, heat transfer, and mass transfer. By aligning design, modeling, and 3D printing, they create customized shapes with great complexity and less material. This approach allows for the creation of bespoke reactors and separation processes tailored to specific applications, improving efficiency and reducing energy consumption. Why it matters: This research demonstrates the potential of advanced manufacturing techniques to revolutionize industrial design in the Middle East's chemical and pharmaceutical sectors.