KAUST researchers developed a statistical approach to improve the identification of cancer-related protein mutations by reducing false positives. The method uses Bayesian statistics to analyze protein domain data from tumor samples, accounting for potential errors due to limited data. The team tested their method on prostate cancer data, successfully identifying a known cancer-linked mutation in the DNA binding protein cd00083. Why it matters: This enhances the reliability of cancer research at the molecular level, potentially accelerating the discovery of new therapeutic targets.
KAUST Professor Hernando Ombao is leading the Biostatistics Group to develop statistical models for projecting hospitalization surges during the COVID-19 pandemic. The group uses techniques like time series analysis and stationary subspace analysis to understand complex biological processes. The models aim to provide public health officials with accurate hospitalization estimates under varying scenarios. Why it matters: This research contributes to preparedness and resource allocation in healthcare systems during public health crises, with potential applications beyond COVID-19.
This paper introduces a novel fuzzy clustering method for circular time series based on a new dependence measure that considers circular arcs. The algorithm groups series generated from similar stochastic processes and demonstrates computational efficiency. The method is applied to time series of wind direction in Saudi Arabia, showcasing its practical potential.
A new framework for constructing confidence sets for causal orderings within structural equation models (SEMs) is presented. It leverages a residual bootstrap procedure to test the goodness-of-fit of causal orderings, quantifying uncertainty in causal discovery. The method is computationally efficient and suitable for medium-sized problems while maintaining theoretical guarantees as the number of variables increases. Why it matters: This offers a new dimension of uncertainty quantification that enhances the robustness and reliability of causal inference in complex systems, but there is no indication of connection to the Middle East.
KAUST Professor Håvard Rue was honored by the Royal Statistical Society (RSS) with the Guy Medal in Silver for his work on efficient computational techniques. The award recognizes Rue's contributions to the theory underpinning the INLA software, particularly through two influential papers on approximate Bayesian inference and Gaussian fields. Rue's research focuses on computational Bayesian statistics and Bayesian methodology, with the R-INLA project being a core part of his work. Why it matters: Recognition of KAUST faculty by international organizations highlights the institution's growing prominence in statistical research and computational modeling.
KAUST researchers from statistics and earth science collaborated to improve earthquake source modeling. They developed a statistical ranking tool to classify 2D fields, applicable to geoscience models like temperature or precipitation. The tool helps compare different 2D fields describing the earthquake source process and quantify inter-event variability. Why it matters: This cross-disciplinary approach enhances the reliability of earthquake rupture models, contributing to better hazard assessment and risk management in seismically active regions.
KAUST Professor Marc Genton and his former postdoc Stefano Castruccio jointly won the 2017 Wilcoxon Award for their paper in Technometrics. Their paper, "Compressing an ensemble with statistical models: An algorithm for global 3D spatio-temporal temperature," details a data-compression scheme for climate simulations. The method reduces data-storage requirements and accelerates climate research capacity. Why it matters: This award highlights KAUST's contribution to statistical methods for climate modeling and big data analysis, particularly relevant for studying renewable energy resources in Saudi Arabia.
KAUST Professor Marc Genton has been selected as the 2020 Georges Matheron Lecturer of the International Association for Mathematical Geosciences. Genton will present a lecture at the 36th International Geological Congress in Delhi, India, focusing on geostatistics, climate model outputs, and the ExaGeoStat software developed at KAUST. His lecture will cover Matheron's theory of regionalized variables and showcase ExaGeoStat, a high-performance software for geostatistics with exascale computing capability developed at KAUST. Why it matters: This recognition highlights KAUST's contributions to advanced statistical methods and high-performance computing in geosciences, enhancing its international reputation in these fields.