A KAUST alumnus presented research on using large language models for complex disease modeling and drug discovery. LLMs were trained on insurance claims of 123 million US people to model diseases and predict genetic parameters. Protein language models were developed to discover remote homologs and functional biomolecules, while RNA language models were used for RNA structure prediction and reverse design. Why it matters: This work highlights the potential of LLMs to accelerate computational biology research and drug development, with a KAUST connection.
Daisuke Kihara from Purdue University presented a seminar at MBZUAI on using deep learning for biomolecular structure modeling. His lab is developing 3D structure modeling methods, especially for cryo-electron microscopy (cryo-EM) data. They are also working on RNA structure prediction and peptide docking using deep neural networks inspired by AlphaFold2. Why it matters: Applying advanced deep learning techniques to biomolecular structure prediction can accelerate drug discovery and our understanding of molecular functions.
Dr. Mikhail Burtsev of the London Institute presented research on GENA-LM, a suite of transformer-based DNA language models. The talk addressed the challenge of scaling transformers for genomic sequences, proposing recurrent memory augmentation to handle long input sequences efficiently. This approach improves language modeling performance and holds promise for memory-intensive applications in bioinformatics. Why it matters: This research can significantly advance AI's capabilities in genomics by enabling the processing of much larger DNA sequences, with potential breakthroughs in understanding and treating diseases.
Researchers at the Rosalind Franklin Institute are using generative AI, including GANs, to augment limited biological datasets, specifically mirtron data from mirtronDB. The synthetic data created mimics real-world samples, facilitating more comprehensive training of machine learning models, leading to improved mirtron identification tools. They also plan to apply Large Language Models (LLMs) to predict unknown patterns in sequence and structure biology problems. Why it matters: This research explores AI techniques to tackle data scarcity in biological research, potentially accelerating discoveries in noncoding RNA and transposable elements.
This article previews a talk by Gül Varol from Ecole des Ponts ParisTech on bridging natural language and 3D human motions. The talk will cover text-to-motion synthesis using generative models and text-to-motion retrieval models based on the ACTOR, TEMOS, TMR, TEACH, and SINC papers. Varol's research interests include video representation learning, human motion synthesis, and sign languages. Why it matters: Research in this area could enable more intuitive human-computer interaction and new applications in areas like virtual reality and robotics.
The InterText project, funded by the European Research Council, aims to advance NLP by developing a framework for modeling fine-grained relationships between texts. This approach enables tracing the origin and evolution of texts and ideas. Iryna Gurevych from the Technical University of Darmstadt presented the intertextual approach to NLP, covering data modeling, representation learning, and practical applications. Why it matters: This research could enable a new generation of AI applications for text work and critical reading, with potential applications in collaborative knowledge construction and document revision assistance.
The paper introduces UAE-3D, a multi-modal VAE for 3D molecule generation that compresses molecules into a unified latent space, maintaining near-zero reconstruction error. This approach simplifies latent diffusion modeling by eliminating the need to handle multi-modality and equivariance separately. Experiments on GEOM-Drugs and QM9 datasets show UAE-3D establishes new benchmarks in de novo and conditional 3D molecule generation, with significant improvements in efficiency and quality.
MBZUAI and GenBio AI have won the UAE AI Award 2025 in the AI Scientific Research category for their "Unified Protein Language Modeling Framework". The winning project enables AI to learn protein function, generate sequences, and predict 3D structures. The AI-driven simulation approach aims to accelerate drug development, reduce costs, and improve success rates. Why it matters: This award highlights the UAE's commitment to fostering AI innovation in biomedicine and drug discovery, positioning the region as a leader in AI-driven healthcare advancements.