Scientists at King Abdullah University of Science and Technology (KAUST) have engineered tiny metal-organic frameworks (MOFs) to deliver a team of six proteins into living cells. Inside the cells, these proteins formed a nanoscale factory that successfully produced violacein, a natural bioactive compound with therapeutic potential. This breakthrough represents the most complex multiprotein system delivered into living cells to date and the first example of a 'protein pathway transplant'. Why it matters: This research offers an early demonstration of how future therapies might generate treatment molecules directly inside the body at disease sites, potentially leading to more precise and less toxic medical interventions.
A KAUST-led team developed a nano-optical chip capable of generating and controlling nanoscale rogue waves. The chip, detailed in Nature Physics, uses a planar photonic crystal fabricated at the University of St. Andrews and tested at FOM Institute AMOLF. It enables unprecedented control over these rare, high-energy events, opening possibilities for energy research and environmental safety. Why it matters: This innovation provides a new platform for studying extreme events and potentially harnessing their energy, advancing both fundamental science and practical applications in areas like renewable energy and disaster prevention.
KAUST faculty members Husam Alshareef, Mario Lanza, and Atif Shamim have been named IEEE Fellows for 2024. They were recognized for work on nanoscale materials for devices, antenna-on-chip tech, and nanoelectronics metrology, respectively. These three are the only inductees from Saudi Arabia and among five from Arab nations. Why it matters: This recognition highlights KAUST's growing prominence as a hub for advanced research and innovation in the Middle East.
KAUST Professor Husam N. Alshareef has been elected as a Fellow of the National Academy of Inventors (NAI). Alshareef, principal investigator of the KAUST Functional Nanomaterials & Devices Laboratory, was selected for his prolific innovation and tangible impact on quality of life, economic development, and welfare of society. Alshareef has authored nearly 520 publications and holds 80 issued patents, with his research focusing on nanoscale materials for electronics and energy applications. Why it matters: This recognition highlights KAUST's contribution to innovation and its researchers' impact on critical technology areas, enhancing the university's international standing and supporting Saudi Arabia's technology leadership goals.
KAUST Professor Husam Alshareef has been elected a Fellow of the Institute of Physics (FInstP), the highest membership level within the IOP. This recognizes his accomplishments in physics and impacts in the sector, stemming from work at KAUST's Functional Nanomaterials & Devices Laboratory. Alshareef's research focuses on developing nanoscale materials for electronics and energy applications, aligning with Saudi Vision 2030. Why it matters: The recognition highlights KAUST's contributions to advanced materials science and its alignment with Saudi Arabia's goals for localizing industries and expanding renewable energy.
KAUST Professor Nikos Hadjichristidis leads the Polymer Synthesis Laboratory, collaborating with Yves Gnanou to manipulate macromolecules at the nanoscale. They employ anionic polymerization using high vacuum techniques, a specialized method requiring handmade glassware and careful control. The team is working on sustainable polymeric materials, including rethinking tire composition to improve recyclability and reduce pollution. Why it matters: This research contributes to developing more sustainable plastics and polymers, addressing a critical environmental challenge while advancing materials science in the region.
KAUST Ph.D. student Amira Alazmi won the Nanoscale poster prize at the Royal Society of Chemistry Symposium 2018 in London for her work on cobalt ferrite/reduced graphene oxide composites as a T2 contrast agent for magnetic resonance imaging. Her research focuses on understanding the synthesis of graphite oxide and reduced graphene oxide. Alazmi's work demonstrates the importance of selecting graphene oxide synthesis methods based on the intended application. Why it matters: This award recognizes the high-impact research being conducted at KAUST and highlights the importance of materials science in advancing medical imaging technologies.
KAUST researcher Corrado Calì won an award at the Brainstorming Research Assembly for Young Neuroscientists (BraYn) in Italy for his work on glycogen modulation and synapse stabilization. Calì presented research in collaboration with KAUST Professor Andrea Falqui and Dr. Elena Vezzoli from the University of Milan, investigating the lactate shuttle's involvement in synaptic plasticity. Calì and KAUST colleagues are also collaborating with the Blue Brain Project to produce a computer simulation of astrocyte-neuron coupling, using 3D virtual reality to investigate brain cell morphologies at the nanoscale. Why it matters: This award recognizes KAUST's contribution to neuroscience research and highlights the university's collaborative efforts in understanding brain plasticity and developing advanced tools for studying brain structures.