Juan Carlos Izpisua Belmonte from the Salk Institute discussed aging and regenerative medicine at the KAUST 2019 Winter Enrichment Program. His team is combining gene editing and stem cell technologies to grow rat organs in mice and human cells in pig and cattle embryos. The Salk team is collaborating with KAUST to rejuvenate organs using noncoding RNAs and small metabolites. Why it matters: This research collaboration between KAUST and the Salk Institute explores innovative approaches to address age-related diseases and organ regeneration, with potential long-term impacts on healthcare in the region.
MBZUAI mourns the passing of UAE President Sheikh Khalifa bin Zayed Al Nahyan. The university offers condolences to the Royal family, the UAE government, and the people. The Ministry of Presidential Affairs declared 40 days of official mourning. Why it matters: This event marks a significant moment of transition and reflection for the UAE and its institutions.
Researchers at MBZUAI have developed a new machine learning method called survival rank-n-contrast (SurvRNC) to improve survival models for cancer prognoses. The method is designed to predict survival times for head and neck cancer patients using multimodal data while accounting for censored data (missing values). Numan Saeed presented the team’s work at the 27th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). Why it matters: Accurate prognoses can significantly improve patient outcomes, and this research contributes to advancements in machine learning techniques for handling complex and incomplete medical data.
KAUST researchers, in collaboration with the Salk Institute and Altos Labs, have identified a class of RNA (LINE-1) that, when compromised, leads to accelerated aging, as seen in progeria. They devised an antisense RNA strategy to block the aberrant function of L1 RNA, reversing the disease in mice and patient-derived cells. Published in Science Translational Medicine, the research suggests that targeting LINE-1 RNA could treat progeroid syndromes and other age-related diseases. Why it matters: This RNA-based approach provides a potential therapeutic avenue for treating premature aging diseases and extending human health span in the region and globally.
A new framework for constructing confidence sets for causal orderings within structural equation models (SEMs) is presented. It leverages a residual bootstrap procedure to test the goodness-of-fit of causal orderings, quantifying uncertainty in causal discovery. The method is computationally efficient and suitable for medium-sized problems while maintaining theoretical guarantees as the number of variables increases. Why it matters: This offers a new dimension of uncertainty quantification that enhances the robustness and reliability of causal inference in complex systems, but there is no indication of connection to the Middle East.
MBZUAI is hosting an "AI Quorum on Statistics for the Future of AI" in Abu Dhabi, focusing on the intersection of statistics and AI in healthcare. Organized by Professors Tian Zheng (Columbia University) and Hongtu Zhu (UNC), the event gathers experts from top global universities and organizations like Eli Lilly and MD Anderson Cancer Center. The workshop aims to integrate statistical insights into AI research, fostering innovations in the field. Why it matters: By convening international experts, MBZUAI is positioning itself as a hub for interdisciplinary AI research with a focus on healthcare applications.
KAUST researchers demonstrated that Beneficial Microorganisms for Corals (BMC) can help corals recover from thermal stress by stimulating immune processes and rebuilding their microbiome. The study, published in Science Advances, showed that probiotic treatments can protect bleached corals from death. The research was conducted at the Federal University of Rio de Janeiro (UFRJ) and the KAUST Red Sea Research Center, with funding from the Great Barrier Reef Foundation and the Tiffany & Co Foundation. Why it matters: This finding offers a promising solution for mitigating the impacts of climate change on coral reefs, which are vital ecosystems facing increasing threats from warming ocean temperatures.
Professor Arnab Pain's group at KAUST discovered new insights on how a malaria protein enables parasites to spread malaria in human cells. Professor Haavard Rue's group upgraded the Integrated and Nested Laplace Approximation (INLA) for faster real-time modeling of large datasets. A KAUST-led study examined the stability of Y-series nonfullerene acceptors for organic solar cells. Why it matters: KAUST continues producing impactful research across diverse fields from medicine to climate change, advancing scientific knowledge and potential applications.