Researchers at KAUST and Peking University Third Hospital have created a novel blastoid model for studying early human development using extended pluripotent stem cells (EPSCs). The blastoid is a 3D cell model mimicking the blastocyst phase, avoiding ethical concerns associated with using human embryos. The team showed that blastoids can be cultured to mimic post-implantation development, offering insights into early cell lineages. Why it matters: This innovation provides a way to study human embryogenesis without the ethical constraints of using actual embryos, potentially advancing our understanding of miscarriage and birth defects.
KAUST Ph.D. student Asma Al-Amoodi received the 2019 L’Oréal-UNESCO For Women in Science Middle East Fellowship for her work on stem cell treatments for hematological diseases. Her research focuses on improving the migration of hematopoietic stem cells to the bone marrow after transplantation. Al-Amoodi was granted €8,000 to support her doctoral research at KAUST under the supervision of Associate Professor Jasmeen Merzaban. Why it matters: The fellowship highlights the increasing role of women in STEM in Saudi Arabia and supports research with potential therapeutic impact.
KAUST's Laboratory of Stem Cells and Diseases, led by Assistant Professor Antonio Adamo, uses induced pluripotent stem cells (iPSCs) to model diseases like diabetes. The lab employs a reprogramming technique to revert patient fibroblasts into iPSCs, enabling the study of disease progression in vitro. Adamo's research focuses on enzymes and disregulated transcriptional/epigenetic mechanisms to understand disease onset. Why it matters: This research contributes to regenerative medicine and offers insights into metabolic diseases relevant to the GCC region.
Khaled Alsayegh at the King Abdullah International Medical Research Center is creating a Saudi Stem Cell Donor Registry, with 80,000 potential donors identified. The aim is to identify universal donors, reprogram their cells into induced pluripotent stem (iPS) cells, and create a gene bank for matched tissue transplants. Alsayegh is collaborating with Jesper Tegnér at KAUST to create pacemaker cells using single-cell RNA sequencing. Why it matters: This initiative could revolutionize precision medicine in KSA by providing readily available, matched cells for transplants, reducing the need for patient-specific reprogramming and improving treatment outcomes.
Researchers from KAUST, King Abdulaziz University, and King Abdulaziz University Hospital conducted a study comparing stem cells from Saudi Klinefelter patients with those from North American and European descent. Klinefelter syndrome affects approximately one in 600 Saudi males, but the MENA population is underrepresented in genomic studies of the disease. The study found a subset of genes on the X chromosome whose dysregulation characterizes Klinefelter syndrome, regardless of geographic origin or ethnicity. Why it matters: This research addresses a gap in understanding the molecular basis of Klinefelter syndrome in the MENA population and provides a platform for further studies of chromosomal diseases.
Eduardo da Veiga Beltrame, bioinformatics lead at ImYoo (a Caltech spinout), presented on scalable methods for single-cell omics data analysis, including kallisto|bustools and scvi-tools. He highlighted their use in ImYoo's decentralized longitudinal study on Inflammatory Bowel Disease (IBD), where patients self-collect capillary blood samples. Beltrame also discussed his research on STEM education programs in Brazil as a visiting scholar at UC Berkeley. Why it matters: This highlights the growing trend of decentralized clinical studies leveraging advanced single-cell technologies for precision medicine, showcasing the potential of remote data collection and analysis in understanding complex diseases.
KAUST alumna Dina Bashir Abusamra, who received her master's degree in 2010 and Ph.D. in 2016 from KAUST, is now a postdoctoral research fellow at the Schepens Eye Research Institute of Massachusetts Eye and Ear, an affiliate of Harvard Medical School. Her early research at KAUST focused on understanding the mechanisms by which transplanted hematopoietic stem cells home back to bone marrow, specifically studying glycan-binding proteins like selectin. She now studies the role of glycan-binding proteins and galectins in microenvironment modulation. Why it matters: This highlights the impact of KAUST in fostering scientific talent and contributing to research in biomedical engineering and bioscience, with alumni now making contributions at leading international research institutions.
The Russian Immune Diversity Atlas project aims to profile immune cells from people of different ancestries at a multiomics level. The goal is to reconstruct a reference atlas of the healthy immune system and investigate its perturbations in Type II Diabetes (T2D). The project seeks to identify novel mechanisms and genetic/epigenetic markers for early T2D diagnostics, prognosis, and therapy as part of the international Human Cell Atlas. Why it matters: Addressing genetic diversity in biomedical research, particularly in the context of the Human Cell Atlas, is crucial for personalized medicine and ensuring that treatments are effective across diverse populations in the Middle East and globally.