KAUST researchers have identified a protein complex of HuR and YB1 that stabilizes messenger RNA during muscle-fiber formation. The complex protects RNA as it carries muscle-forming code through the cell. Further research aims to elucidate the individual roles of each protein in the stabilization process. Why it matters: Understanding this RNA-stabilizing complex could lead to new therapies for muscle recovery and the prevention of muscle-related pathologies.
KAUST researchers are exploring the link between nutrition and brain-energy metabolism to address cognitive decline, dementia, and Alzheimer’s disease. Dr. Pierre Magistretti and Dr. Johannes le Coutre are collaborating on ways to merge brain-energy metabolism research into the field of nutrition. They published an article entitled “Goals in Nutrition Science 2015-2020” in the journal Frontiers in Nutrition. Why it matters: This research could lead to nutritional interventions to hinder or prevent cognitive decline, offering a new approach beyond traditional drug treatments.
KAUST's Laboratory of Stem Cells and Diseases, led by Assistant Professor Antonio Adamo, uses induced pluripotent stem cells (iPSCs) to model diseases like diabetes. The lab employs a reprogramming technique to revert patient fibroblasts into iPSCs, enabling the study of disease progression in vitro. Adamo's research focuses on enzymes and disregulated transcriptional/epigenetic mechanisms to understand disease onset. Why it matters: This research contributes to regenerative medicine and offers insights into metabolic diseases relevant to the GCC region.
KAUST researcher Corrado Calì won an award at the Brainstorming Research Assembly for Young Neuroscientists (BraYn) in Italy for his work on glycogen modulation and synapse stabilization. Calì presented research in collaboration with KAUST Professor Andrea Falqui and Dr. Elena Vezzoli from the University of Milan, investigating the lactate shuttle's involvement in synaptic plasticity. Calì and KAUST colleagues are also collaborating with the Blue Brain Project to produce a computer simulation of astrocyte-neuron coupling, using 3D virtual reality to investigate brain cell morphologies at the nanoscale. Why it matters: This award recognizes KAUST's contribution to neuroscience research and highlights the university's collaborative efforts in understanding brain plasticity and developing advanced tools for studying brain structures.
KAUST and King Abdulaziz University (KAU) are collaborating to develop low-cost sodium-ion battery technology using fly ash, a waste material from burning fossil fuels. Researchers are purifying fly ash and using thermal treatment to engineer its structure for use as carbon electrodes in batteries. The resulting carbon electrode material is competitive with existing market products and can be used for other applications. Why it matters: This research offers a sustainable approach to energy storage by repurposing waste materials, potentially enabling cheaper and more environmentally friendly grid-scale energy storage for renewable energy sources.
KAUST researchers used cryogenic electron microscopy (cryo-EM) to study the 3D structure of protein complexes involved in DNA replication and repair. They investigated the interaction between the Y-family TLS polymerase Pol K and mono-ubiquitylated PCNA. The study revealed that DNA binding is required for Pol K to form a rigid, active complex with PCNA. Why it matters: Understanding these structural interactions may provide insights into cancer development and drug resistance mechanisms.
MIT Professor Ahmed F. Ghoniem delivered a keynote at KAUST's Spring Enrichment Program discussing clean energy solutions for future cities. He emphasized a portfolio approach including electrochemical, solar thermochemical, and plasma technologies for renewable energy storage. Ghoniem highlighted the economic opportunities arising from clean energy technology deployment, R&D, and job creation. Why it matters: The focus on renewable energy and storage aligns with Saudi Arabia's Vision 2030 goals for sustainable urban development and diversification of the energy sector.
KAUST researchers used electron tomography and X-ray photoelectron spectroscopy to study charge storage in manganese oxide electrodes for supercapacitors. They found that the electrolyte etches nanoscale openings in the manganese oxide sheets, increasing electrolyte permeability and energy density during cycling. 3D tomography revealed how the electrode's morphological evolution increases its surface area, enhancing energy densities. Why it matters: The research provides insights into improving the cycling stability of pseudocapacitive materials, which are crucial for developing high-performance supercapacitors.