KAUST researchers led by Dr. Niveen Khashab have developed thermosensitive liposomes for controlled drug release, particularly in cancer therapies. The liposomes are designed to release drugs only when they reach heated tumor tissue, minimizing systemic side effects. Cholesterol moieties are used as anchors to create a "nail" or "comb" effect, enabling temperature-triggered drug release inside cells. Why it matters: This targeted drug delivery system could significantly improve the efficacy and reduce the toxicity of cancer treatments.
KAUST Ph.D. student Khalil Moussi won two awards at the IEEE International Conference on Nano/Micro Engineered and Molecular Systems for his research on a miniaturized drug delivery system. The system, developed in collaboration with KAIMRC, uses 3D printing and wireless power to deliver drugs for coronary artery disease treatment. The device features an electrochemical micro-pump, a 3D printed reservoir with microneedles, and a wireless powering unit, allowing customization for various in vivo drug delivery applications. Why it matters: This recognition highlights KAUST's contributions to biomedical engineering and its potential to develop innovative solutions for critical healthcare challenges in the region and beyond.
Shahar Harel, Head of AI at Quris, presented a BIO-AI approach to drug safety assessment using a 'patient-on-a-chip' platform. This platform simulates the human body and generates high-frequency microscopy and biochemical data on drug interactions, considering patient genomics and ethnicity. The data is used to train multimodal deep learning models to predict drug safety and provide patient-specific recommendations. Why it matters: This approach offers a potential alternative to animal models, promising faster and more personalized drug development while reducing safety concerns.
MBZUAI's Professor Le Song is developing an AI-driven simulation to model the human body at societal, organ, tissue, cellular, and molecular levels. The goal is to reduce the time and cost associated with bringing new medicines to market by removing the need for wet lab biological research. Song aims to create a comprehensive model using machine learning. Why it matters: This research could revolutionize drug discovery in the region by accelerating the development process and reducing reliance on traditional research methods.
A KAUST team led by Hossein Fariborzi won second place in the MEMS Design Contest for their "MEMS Resonator for Oscillator, Tunable Filter and Re-Programmable Logic Applications." The device is runtime-reprogrammable, allowing the function of each device in the circuit to be changed during operation. The KAUST team demonstrated that two MEMS resonators could replace over 20 transistors in applications like digital adders, reducing digital circuit complexity. Why it matters: This innovation could significantly reduce power consumption, chip area, and manufacturing costs in microprocessors, advancing the development of energy-efficient microcomputers in the region.
The Technology Innovation Institute (TII) in Abu Dhabi has launched a 2-micrometer high-power fiber laser for medical and industrial applications. Developed by TII's Directed Energy Research Center, the Thulium-based laser is efficient, compact, and scalable, enabling precise interaction with water-rich materials. TII has partnered with LIMA Photonics, a German MedTech startup, to integrate the laser into clinical solutions, including urinary stone treatment and prostate surgery. Why it matters: This laser technology and partnership showcase the UAE's commitment to translating advanced research into healthcare solutions, positioning Abu Dhabi as a hub for medical technology innovation.