Dr. John Bedbrook of DiCE Molecules LLC spoke at KAUST about the challenges of feeding a growing population with increasingly stressed arable land. He noted the increasing demand for meat in emerging economies exacerbates the problem. Bedbrook emphasized the role of genetics and hybridization in improving crop yields and quality to address food security. Why it matters: Investments in agricultural biotechnology are crucial for the GCC region to enhance food security and reduce reliance on imports amid changing climate conditions.
KAUST researchers are working to improve gene editing tools, specifically CRISPR/Cas9, for crop bioengineering to address food security challenges. Magdy Mahfouz's lab is developing a germline engineering platform to produce gene-edited plants without foreign DNA and bypass time-consuming tissue culture. A recent European court decision classifies CRISPR/Cas9 crops as GMOs, facing stringent regulations, contrasting with the U.S. where CRISPR-edited mushrooms are already available. Why it matters: Advances in gene editing at KAUST could significantly enhance crop yields and stress tolerance in the region, but regulatory hurdles remain a key challenge for deployment.
KAUST plant scientists are advocating for the deployment of new plant breeding technologies, including gene editing, to enhance global food security. Researchers Mark Tester and Magdy Mahfouz highlight these methods' potential to improve crops by minimizing crop life cycle for research on breeding, selection, and fixing of useful genes. They argue these technologies offer alternatives to genetically modified crops, potentially lowering regulatory costs and increasing seed affordability for farmers in developing countries. Why it matters: These advancements, coupled with regional seed-sharing initiatives, could significantly boost food production and accessibility in less-developed countries in the Middle East and globally.
KAUST Professor Salim Al-Babili is working to improve crop performance and nutritional value, with a focus on pearl millet. He received a $5 million grant from the Gates Foundation in 2018 to combat the parasitic plant Striga hermonthica, which causes billions in losses annually in Sub-Saharan Africa. His team is developing hormone-based strategies to protect pearl millet from Striga infestation, a project spanning lab research to field trials in Saudi Arabia and Africa. Why it matters: This research addresses critical food security challenges in both Africa and the Middle East by developing practical tools for smallholder farmers, bridging the gap between lab discoveries and real-world applications.
NYU Professor Michael Purugganan presented at KAUST's 2014 Winter Enrichment Program (WEP 2014) on the origins of crop species. He discussed how genome sequencing is improving our understanding of crop evolution, using date fruits collected in Jeddah as an example. His research on rice showed that two varieties, japonica and indica, share a single common ancestor, contrary to previous assumptions. Why it matters: Understanding crop evolution can help adapt crops to changing environments, which is crucial for food security in regions like the Middle East.
KAUST professors Samir Hamdan and Nina Fedoroff collaborated on research published in Nucleic Acids Research focusing on microRNA (miRNA) biogenesis in plants. The study examined miRNA production in Arabidopsis thaliana and found that the protein SERRATE (SE) is integral to the processing of pri-miRNA by DCL1. They characterized the interactions of SE with RNA and DCL1, elucidating the mechanism by which SE promotes DCL1 activity. Why it matters: Understanding miRNA biogenesis could help modify crop plants to better tolerate stressful conditions, potentially increasing crop yields and productivity in the region.
KAUST researchers are studying the chemical signals in pearl millet that trigger the germination of Striga seeds, a parasitic plant. The research aims to understand the biological compounds involved in Striga infestation. The goal is to induce Striga germination without host plants, reducing Striga seed banks in infested soils. Why it matters: Addressing Striga infestation can improve crop yields and food security, especially in regions relying on pearl millet.
KAUST's Center of Excellence for Sustainable Food Security (CoE-SFS) has launched 12 translation projects focused on plant growth and water security, establishing partnerships with public and private entities to scale up research. Mark Tester's team developed stress-tolerant rootstocks, grafted onto crops like tomatoes, that thrive in hot, dry conditions with increased yields. Through his start-up Iyris, Tester is conducting commercial field trials in over 12 countries. Why it matters: These efforts to adapt agriculture to environmental change are crucial for ensuring food security in Saudi Arabia, the region, and globally, especially in the face of climate change and limited water resources.