Researchers from KAUST, King Faisal Specialist Hospital, and collaborators have developed a new method to predict cardiometabolic disease risk in underrepresented ethnic populations using genetic information and public databases. The study focused on Arab communities and created a framework to determine polygenic scores for more accurate heart disease prediction. The framework was validated using records of over 5,000 Arab patients, demonstrating that genetic risk complements conventional risk factors. Why it matters: This research addresses a critical gap in genomic data for non-European populations, potentially leading to more effective and personalized healthcare strategies in the Arab world and beyond.
KAUST researchers have identified the gene 'CIROZ' as responsible for pediatric heart defects and misplacement of internal organs, working with institutes in Saudi Arabia and worldwide. The research examined samples from 16 patients from 10 families, including four from Saudi Arabia, revealing CIROZ's role in embryonic development symmetry. The findings provide insights into heritable diseases, which are more prevalent in Saudi Arabia. Why it matters: Identifying this gene allows for focused research on preventative strategies and curative therapies for congenital heart defects, particularly relevant in regions with higher rates of such diseases.
MBZUAI alumnus Ikboljon Sobirov is using AI to develop new diagnostic tools for cardiovascular disease at the University of Oxford. His research focuses on building imaging biomarkers by integrating transcriptomic data with medical scans. The goal is to predict how a patient will respond to specific medications using only images. Why it matters: This work showcases the potential of AI and multi-modal data to personalize medicine and improve healthcare outcomes in the region and globally.
Pong C Yuen from Hong Kong Baptist University will present a talk on remote photoplethysmography (rPPG) detection. The talk will review the development of rPPG detection, share recent research, and discuss future directions. rPPG is a technology for non-contact computer vision and healthcare applications like heart rate estimation. Why it matters: Advancements in rPPG could enable new remote patient monitoring and diagnostic tools in the region, reducing the need for physical contact.
MBZUAI researchers are developing AI applications for malaria prevention in Indonesia using sensory data fusion and digital twins. Another MBZUAI team is using machine learning and computer vision to detect cardiovascular disease from CT scans in collaboration with the University of Oxford. AI-powered remote patient monitoring is also being explored for proactive interventions and chronic disease management. Why it matters: These projects demonstrate the potential of AI to address healthcare challenges in underserved communities and improve disease prevention and management in the region.
MBZUAI and Abu Dhabi Health Services Company (SEHA) are collaborating to develop AI algorithms to predict heart attacks months in advance with 87% accuracy using ultrasound images. The project aims to preemptively predict heart attacks in the short and long term, addressing the high rates of cardiac arrest, especially in the Middle East. A Memorandum of Understanding (MoU) was signed between SEHA and MBZUAI to integrate AI into healthcare. Why it matters: This partnership could significantly improve healthcare outcomes in the region by leveraging AI to proactively address heart disease, a leading cause of death.
This paper introduces a self-supervised contrastive learning method for segmenting the left ventricle in echocardiography images when limited labeled data is available. The approach uses contrastive pretraining to improve the performance of UNet and DeepLabV3 segmentation networks. Experiments on the EchoNet-Dynamic dataset show the method achieves a Dice score of 0.9252, outperforming existing approaches, with code available on Github.
Khaled Alsayegh at the King Abdullah International Medical Research Center is creating a Saudi Stem Cell Donor Registry, with 80,000 potential donors identified. The aim is to identify universal donors, reprogram their cells into induced pluripotent stem (iPS) cells, and create a gene bank for matched tissue transplants. Alsayegh is collaborating with Jesper Tegnér at KAUST to create pacemaker cells using single-cell RNA sequencing. Why it matters: This initiative could revolutionize precision medicine in KSA by providing readily available, matched cells for transplants, reducing the need for patient-specific reprogramming and improving treatment outcomes.