Researchers at King Abdullah University of Science and Technology (KAUST) have developed a novel genome engineering method for precisely inserting large pieces of genetic information into plants. Published in Nature Biotechnology, this approach allows for targeted placement of large genes into plant genomes without creating DNA breaks, overcoming a long-standing challenge in the field. The method was successfully demonstrated in both tobacco and rice, opening new possibilities for agricultural biotechnology and synthetic biology. Why it matters: This advance could enable the development of more complex traits in crops for improved resilience and sustainable agriculture, and facilitate the use of plants as scalable platforms for producing therapeutics and other valuable compounds.
The Saudi Vaccine and Biomanufacturing Center (SVBC), the first of its kind in the Middle East, broke ground at KAUST on December 15. The center will develop vaccines and biopharmaceutical products under good manufacturing practice (GMP) standards. It is a joint project championed by the Ministry of Energy, Industry and Mineral Resources through the Industrial Clusters Program and supported by KACST. Why it matters: The center will serve as a national platform for pharmaceutical innovation and address epidemic risks in the Kingdom, such as MERS-CoV.
The Research Products Development Company (RPDC) signed an agreement with The Saudi Vaccine and Biomanufacturing Center (SVBC) to establish a research and industrial center in Saudi Arabia for vaccine and biopharmaceutical development. Supported by KACST and hosted by KAUST, the SVBC will provide a state-of-the-art facility and a training platform. Cooperation agreements were also signed with GE for equipment supply and with Fujifilm Dayosent Biotechnology for MERS-CoV treatment development. Why it matters: This initiative aims to localize vaccine and advanced treatment industries in Saudi Arabia, create technical jobs, and reduce reliance on imports in line with Vision 2030.
KAUST's Bioscience Core Lab (BCL) supports regional and global health initiatives through industry partnerships, offering expertise and technology access to organizations like SaudiVax. BCL aids SaudiVax in developing vaccines and monoclonal antibodies tailored to the needs of Saudi Arabia and the MENA region, focusing on respiratory diseases like MERS and COVID-19. SaudiVax is also collaborating with KAUST to research a new preventative drug targeting SARS-CoV-2. Why it matters: This strengthens Saudi Arabia's capabilities in vaccine development and biomanufacturing, addressing critical healthcare needs in the region and reducing reliance on external sources.