MBZUAI researchers developed a machine-learning method to predict antimicrobial resistance (AMR) by analyzing electronic health records. The system predicts if a patient will experience AMR when prescribed an antibiotic or if infected with a bacterium. Published in Scientific Reports, the innovation helps physicians identify patients at risk for AMR by using patient demographics, lab results, and physician notes. Why it matters: This approach can help combat the rise of drug-resistant bacteria by providing timely predictions and supporting more informed prescription decisions.
KAUST researchers have discovered that combining ultraviolet sunlight with phages increases the susceptibility of antibiotic-resistant bacteria to sunlight disinfection. This breakthrough addresses the growing threat of antimicrobial resistance, as the rate of discovering new antibiotics has slowed. The team demonstrated this method's effectiveness against a pathogenic E. coli strain found in Saudi wastewater. Why it matters: This research offers a promising alternative to traditional antibiotics, particularly relevant in regions like Singapore and the GCC where treated wastewater is a crucial water supply source.
KAUST's Computational Bioscience Research Center (CBRC) and King Abdulaziz City for Science and Technology (KACST) have collaborated on research into methicillin-resistant Staphylococcus aureus (MRSA) within Saudi Arabia, starting in July 2018. The two-year project aims to understand MRSA drug resistance mechanisms specific to the Kingdom and its regions, with the goal of developing public health strategies. The project involves sequencing samples and performing bioinformatics analysis to support a network of researchers in the country. Why it matters: This initiative enhances Saudi Arabia's capacity to predict, prevent, and control infectious diseases, aligning with national health objectives and building local expertise in computational bioscience.
KAUST and the SFDA co-hosted the "Trends in Microbiome and Digital One Health" conference from October 30 to November 1, 2023, featuring 35 speakers from five continents. Discussions centered on microbiome science, digital tools for tracking microbial epidemiology, and their roles in the One Health concept. The conference facilitated the formation of a consortium for microbiome and Digital One Health research. Why it matters: This event highlights Saudi Arabia's growing focus on leveraging microbiome research and digital technologies to address public health challenges and promote international collaboration in the field.
The KAUST Pathogen Genomics Laboratory (PGL), led by Professor Arnab Pain, is using DNA and RNA sequencing to study the SARS-CoV-2 virus. The lab is part of KAUST's Rapid Research Response Team (R3T), supporting Saudi healthcare stakeholders in combating COVID-19. Pain and his Ph.D. student Sharif Hala are partnering with the Saudi-CDC and Ministry of Health hospitals to sequence Saudi SARS-CoV-2 samples. Why it matters: This effort provides crucial data for understanding and monitoring the virus's spread and evolution within the Kingdom, informing public health strategies.
KAUST Professor Raquel Peixoto will co-lead the first global body under the International Union for Conservation of Nature (IUCN) to safeguard microbial biodiversity. The Microbial Conservation Specialist Group will explore ecological disruption and potential extinction of microbes vital to ecosystems and human health. The group will assess extinction risks, set conservation priorities, and establish criteria for a microorganism Red List. Why it matters: This initiative highlights the growing recognition of the importance of microbial ecosystems and positions KAUST as a leader in integrating microbiology into global biodiversity governance.
A KAUST scientist led a global call for climate solutions, published simultaneously by 14 academic journals and released at COP29. The publication, prepared by 18 scientists, urges international governments to deploy microbial 'vaccines' against climate change. Six simple 'vaccine' examples are outlined, including carbon sequestration boosters and methane busters. Why it matters: This coordinated effort highlights the urgency of addressing climate change and KAUST's leading role in microbial solutions.
Researchers at KAUST and international collaborators have published a framework in Nature Microbiology for using microbiomes to protect wildlife. The framework outlines a path from laboratory research to large-scale applications of microbiome solutions for threatened ecosystems. It addresses ethical considerations and risk assessment for applying environmental probiotics. Why it matters: This framework provides a science-based guide for responsible research and development of microbiome solutions to combat global biodiversity loss, particularly in sensitive marine ecosystems like coral reefs.