KAUST researchers used cryogenic electron microscopy (cryo-EM) to study the 3D structure of protein complexes involved in DNA replication and repair. They investigated the interaction between the Y-family TLS polymerase Pol K and mono-ubiquitylated PCNA. The study revealed that DNA binding is required for Pol K to form a rigid, active complex with PCNA. Why it matters: Understanding these structural interactions may provide insights into cancer development and drug resistance mechanisms.
Michael Waterman, professor at USC, and Wei Wang, director at UCLA, gave keynote addresses at KAUST. Charlotte Hauser, KAUST professor of bioscience, also gave a keynote lecture. Peer Bork (EMBL) and Martin Noble spoke with Vladimir Bajic at the event. Why it matters: This indicates KAUST's ongoing engagement with international experts to advance research in computational biology.
KAUST researchers, in collaboration with the Salk Institute and Altos Labs, have identified a class of RNA (LINE-1) that, when compromised, leads to accelerated aging, as seen in progeria. They devised an antisense RNA strategy to block the aberrant function of L1 RNA, reversing the disease in mice and patient-derived cells. Published in Science Translational Medicine, the research suggests that targeting LINE-1 RNA could treat progeroid syndromes and other age-related diseases. Why it matters: This RNA-based approach provides a potential therapeutic avenue for treating premature aging diseases and extending human health span in the region and globally.
KAUST has launched REVelate, a corporate innovation program aimed at mid and senior management of Saudi-based companies. The four-month program includes lectures, workshops, and mentoring to develop projects important to the participating companies. It is designed to foster an 'intrapreneurship' culture and enhance the innovation capacity of KAUST industry partners. Why it matters: This initiative addresses a critical need for corporate innovation methodologies in Saudi Arabia, potentially boosting the performance and competitiveness of local companies.