Researchers at King Abdullah University of Science and Technology (KAUST) found that restoring a key cellular molecule, NAD+, can partially reverse the effects of acidic stress in human cells. Published in Communications Biology, their study utilized a precisely controlled bioreactor system to investigate how mild extracellular acidity disrupts cellular energy generation and mitochondrial function. The research identified NAD+ depletion as a key underlying mechanism and demonstrated that NMN supplementation partially restored cellular function and reduced mitochondrial dysfunction. Why it matters: These findings could inform future strategies to protect cells and support human health, particularly in diseases like cancer and inflammation where acidic conditions are common.
KAUST and Oxford Nanopore Technologies have signed an MoU to collaborate on multi-omics research, building on previous work such as the NanoRanger technique developed by KAUST's Mo Li. KAUST will gain early access to Oxford Nanopore’s sequencing technology, while Oxford Nanopore will access KAUST's Core Labs. Why it matters: This partnership enhances KAUST's research capabilities in areas like rare diseases and desert agriculture, and provides Oxford Nanopore with a launchpad to engage with Saudi Arabia's research community.
KAUST and Saudi healthtech company amplifAI health have signed an MoU to develop a new disease detection system. The system will combine amplifAI's AI technology with KAUST's HyplexTM hyperspectral imaging, initially for diabetic foot complications. Clinical trials are planned, with aims to reduce amputations and save Saudi Arabia over 2 billion Riyals annually. Why it matters: This partnership showcases the potential of combining Saudi AI and advanced imaging technologies to address pressing healthcare challenges in the region, particularly diabetes.
KAUST researchers, in collaboration with the Salk Institute and Altos Labs, have identified a class of RNA (LINE-1) that, when compromised, leads to accelerated aging, as seen in progeria. They devised an antisense RNA strategy to block the aberrant function of L1 RNA, reversing the disease in mice and patient-derived cells. Published in Science Translational Medicine, the research suggests that targeting LINE-1 RNA could treat progeroid syndromes and other age-related diseases. Why it matters: This RNA-based approach provides a potential therapeutic avenue for treating premature aging diseases and extending human health span in the region and globally.
Three KAUST students, Mohammed Zidan, Joanna Nasser, and Stephanie Saade, were selected to attend the 65th Lindau Nobel Laureate Meeting in Germany. The meeting will host 65 Nobel Laureates and 650 young researchers in physiology, medicine, physics, and chemistry. The students look forward to the transfer of knowledge and networking opportunities with leading scientists. Why it matters: This recognition highlights KAUST's commitment to fostering young scientific talent and providing opportunities for them to engage with the global scientific community.
KAUST professor Pierre Magistretti has been elected to the Norwegian Academy of Science and Letters. His election recognizes his contributions to neuroscience, specifically his work on lactate's role in brain function. Magistretti's research focuses on the lactate shuttle system and how neurons and glial cells cooperate to meet energy demands. Why it matters: This honor highlights KAUST's contribution to international neuroscience and can foster further collaboration in the field.
The Technology Innovation Institute (TII) in Abu Dhabi has launched a 2-micrometer high-power fiber laser for medical and industrial applications. Developed by TII's Directed Energy Research Center, the Thulium-based laser is efficient, compact, and scalable, enabling precise interaction with water-rich materials. TII has partnered with LIMA Photonics, a German MedTech startup, to integrate the laser into clinical solutions, including urinary stone treatment and prostate surgery. Why it matters: This laser technology and partnership showcase the UAE's commitment to translating advanced research into healthcare solutions, positioning Abu Dhabi as a hub for medical technology innovation.