KAUST researchers have captured the initial unwinding of DNA using cryo-electron microscopy and deep learning. The study details 15 atomic states describing how the Simian Virus 40 Large Tumor Antigen helicase unwinds DNA, revealing the coordinated roles of DNA, helicases, and ATP. The research elucidates the fundamental mechanisms of DNA replication, a cornerstone of growth and reproduction. Why it matters: This detailed understanding of helicase function could lead to advances in nanotechnology and our understanding of genetic processes.
KAUST researchers, led by Mohamed Eddaoudi, developed a metal-organic framework (MOF) capable of selectively adsorbing water, challenging the conventional view of MOF instability in water. They also advanced MOF understanding by adapting high-resolution transmission electron microscopy to observe their atomic structure. KAUST hosted the Innovation to Impact Roundtable, fostering collaboration between academics and industry leaders from the U.S. and Saudi Arabia. Why it matters: These activities highlight KAUST's role in materials science innovation and fostering international research collaborations to advance technological development in Saudi Arabia.
KAUST researchers developed a water-stable MOF for energy-efficient dehydration, overturning conventional views. They also adapted high-resolution transmission electron microscopy to observe the atomic structure of metal-organic frameworks. KAUST hosted the Innovation to Impact Roundtable, fostering collaboration between academics and industry leaders from the U.S. and Saudi Arabia. Why it matters: These activities highlight KAUST's commitment to research breakthroughs, talent development, and fostering international collaborations in science and technology.
KAUST researchers used cryogenic electron microscopy (cryo-EM) to study the 3D structure of protein complexes involved in DNA replication and repair. They investigated the interaction between the Y-family TLS polymerase Pol K and mono-ubiquitylated PCNA. The study revealed that DNA binding is required for Pol K to form a rigid, active complex with PCNA. Why it matters: Understanding these structural interactions may provide insights into cancer development and drug resistance mechanisms.
KAUST Professor Yu Han has received the Humboldt Research Award for his work in nanostructured materials and electron microscopy. The award sponsors a research project in Germany in collaboration with experts at a German institution; Han was nominated by Dr. Stefan Kaskel at Technische Universität Dresden (TU Dresden). Han will visit TU Dresden to explore collaborations in nanoporous materials and electron microscopy, expanding on an existing project imaging flexible metal-organic frameworks. Why it matters: The award recognizes KAUST's contributions to advanced materials research and facilitates international collaboration in a key area for catalysis and separation technologies.
KAUST researchers collaborated with the Blue Brain Project to study astrocytes, brain cells crucial for memory and learning. Dr. Corrado Calì produced 3D models of astrocytes using serial block-face electron microscopy to understand their structure. The study, published in Progress in Neurobiology, reveals how lactate transfer from astrocytes to neurons contributes to brain energy usage. Why it matters: Understanding astrocyte function could lead to new drugs for treating conditions like stroke and Alzheimer's disease by improving brain cell function.
KAUST has signed a worldwide agreement with Thermo Fisher Scientific, granting the company access to two KAUST patents related to high-resolution transmission electron microscopy (HRTEM). The patents enable atomic-resolution TEM imaging of electron beam–sensitive crystalline materials by minimizing beam damage using low doses of electrons. The technology also improves alignment of nano-sized crystals and delivers high signal-to-noise ratio images. Why it matters: This partnership enhances KAUST's role as a global technology university and strengthens Saudi Arabia's position as a hub for scientific advancement in materials science.
KAUST researchers developed a new methodology for high-resolution transmission electron microscopy (TEM) imaging of beam-sensitive materials. The method addresses challenges in acquiring images with low electron doses, aligning images, and determining defocus values. The processes incorporate two provisional patents and are applicable to aligning nanosized crystals and noisy images with periodic features. Why it matters: This advancement enables the study of delicate materials like MOFs at atomic resolution, with broad applications in materials science and nanotechnology.