KAUST researchers developed a new methodology for high-resolution transmission electron microscopy (TEM) imaging of beam-sensitive materials. The method addresses challenges in acquiring images with low electron doses, aligning images, and determining defocus values. The processes incorporate two provisional patents and are applicable to aligning nanosized crystals and noisy images with periodic features. Why it matters: This advancement enables the study of delicate materials like MOFs at atomic resolution, with broad applications in materials science and nanotechnology.
KAUST researchers used cryogenic electron microscopy (cryo-EM) to study the 3D structure of protein complexes involved in DNA replication and repair. They investigated the interaction between the Y-family TLS polymerase Pol K and mono-ubiquitylated PCNA. The study revealed that DNA binding is required for Pol K to form a rigid, active complex with PCNA. Why it matters: Understanding these structural interactions may provide insights into cancer development and drug resistance mechanisms.
KAUST researchers used electron tomography and X-ray photoelectron spectroscopy to study charge storage in manganese oxide electrodes for supercapacitors. They found that the electrolyte etches nanoscale openings in the manganese oxide sheets, increasing electrolyte permeability and energy density during cycling. 3D tomography revealed how the electrode's morphological evolution increases its surface area, enhancing energy densities. Why it matters: The research provides insights into improving the cycling stability of pseudocapacitive materials, which are crucial for developing high-performance supercapacitors.
KAUST and Thermo Fisher Scientific launched an Electron Microscopy Center of Excellence on May 9. The Center expands the existing partnership between KAUST and Thermo Fisher, focusing on instrument performance and R&D collaboration. It features the FEI Titan Themis Z scanning transmission electron microscope, the first installation globally. Why it matters: The center will provide advanced materials science research capabilities to KAUST researchers, industry partners, and Saudi Arabia, enhancing scientific discovery and technological advancement in the region.
KAUST researchers developed a crystallization process for organic molecules with potential applications in electronics, pharmaceuticals, and food. They produced "strained organic semiconductors," which can lead to high-performance, low-cost, flexible, and transparent electronic devices. The team combined X-ray beams with high-speed cameras to record the crystallization process, revealing that quick evaporation and nanoscale thinness play a role in producing ideal crystal lattices. Why it matters: This new method offers unprecedented control over crystal formation, potentially revolutionizing the production of plastic electronics and impacting other industries relying on specific crystal structures.
KAUST hosted the Electron Microscopy Frontiers conference from December 9-11, marking five years of electron microscopy activities at the university. The symposium featured over 20 speakers from international universities and research institutions. It aimed to foster scientific collaborations and showcase KAUST's growing role as a leading electron microscopy laboratory in the Middle East. Why it matters: The conference signals KAUST's ambition to become a hub for advanced microscopy research and collaboration in the region, potentially driving innovation in materials science and bioscience.
KAUST researchers, in collaboration with Nanyang Technological University, have discovered a unique chiral structure in gold nanowires. The nanowires exhibit a Boerdijk-Coxeter-Bernal (BCB) helix structure, achieved through a seed-mediated substrate growth method, reaching a minimum diameter of 3 nanometers. High-resolution transmission electron microscopy (HRTEM) at KAUST was crucial in revealing the structure. Why it matters: This breakthrough in chiral metallic nanowire production could lead to advancements in chemical separation, sensing, and catalysis due to the unique properties of chiral crystals.
KAUST Discovery Associate Professor Stefan Arold has established KAUST's first structural biology lab specializing in determining the atomic 3D structure of proteins and other biological macromolecules. The lab setup involved challenges such as assembling instruments and continuing research, but the Bioscience Core Lab at KAUST and support from colleagues aided in the process. Arold's research focuses on understanding protein function through an integrated 'hybrid' approach to analyze 3D structure and function of proteins. Why it matters: This new lab enhances KAUST's capabilities in molecular biophysics and structural biology, enabling advanced research into the functions of proteins and their implications for health and disease.