Juan Carlos Izpisua Belmonte from the Salk Institute discussed aging and regenerative medicine at the KAUST 2019 Winter Enrichment Program. His team is combining gene editing and stem cell technologies to grow rat organs in mice and human cells in pig and cattle embryos. The Salk team is collaborating with KAUST to rejuvenate organs using noncoding RNAs and small metabolites. Why it matters: This research collaboration between KAUST and the Salk Institute explores innovative approaches to address age-related diseases and organ regeneration, with potential long-term impacts on healthcare in the region.
KAUST researchers, in collaboration with the Salk Institute and Altos Labs, have identified a class of RNA (LINE-1) that, when compromised, leads to accelerated aging, as seen in progeria. They devised an antisense RNA strategy to block the aberrant function of L1 RNA, reversing the disease in mice and patient-derived cells. Published in Science Translational Medicine, the research suggests that targeting LINE-1 RNA could treat progeroid syndromes and other age-related diseases. Why it matters: This RNA-based approach provides a potential therapeutic avenue for treating premature aging diseases and extending human health span in the region and globally.
Nobel laureate Dr. Michael Young from Rockefeller University presented his research on circadian rhythms at KAUST as part of the 2019 Winter Enrichment Program. His work on Drosophila genes has significantly advanced the understanding of circadian rhythm mechanisms. Young's research identified nine genes that regulate circadian rhythmicity at the molecular level, influencing thousands of gene expression patterns. Why it matters: This highlights KAUST's role in hosting leading international researchers and fostering scientific exchange on fundamental biological processes.
Dr. Paolo Sassone-Corsi from UC Irvine spoke at KAUST's 2019 Winter Enrichment Program about circadian rhythms. He discussed how modern lifestyles disrupt our internal clocks, impacting our health and metabolism. Studies show that the timing of food intake affects weight gain, with eating late at night causing metabolic stress. Why it matters: This highlights the importance of circadian rhythm research for understanding and mitigating the health consequences of modern lifestyles in the region.
American artist Rachel Sussman spoke at KAUST's 2019 Winter Enrichment Program about her project documenting the world's oldest living organisms. Sussman photographed 30 species alive for over 2,000 years, including trees, coral, and bacteria. She collaborated with 30 scientists to identify and document these organisms. Why it matters: The lecture highlights KAUST's interdisciplinary approach to knowledge, connecting art, science, and philosophy to explore concepts of time and longevity.