Making sense of silence in gene regulatory networks

Summary

MBZUAI researchers collaborated with Carnegie Mellon University and the Broad Institute of MIT and Harvard to develop a new statistical method for analyzing data used for gene regulatory network inference. The method addresses the challenge of distinguishing true zero expression values from dropouts in single-cell RNA sequencing data. This research will be presented at the Twelfth International Conference on Learning Representations (ICLR 2024). Why it matters: Improving gene regulatory network inference can lead to better understanding of disease mechanisms and inform the development of new medicines.