MBZUAI researchers co-led a study published in Nature demonstrating that GluFormer, an AI foundation model trained on continuous glucose monitoring (CGM) data, more accurately predicts long-term diabetes and cardiovascular risk than current clinical standards. GluFormer, built on a transformer architecture and trained using NVIDIA AI infrastructure on over 10 million CGM measurements, forecasts individual health risks using short-term glucose dynamics. In a 12-year follow-up, the model captured 66% of new-onset diabetes cases and 69% of cardiovascular-death events in its highest-risk group, outperforming established CGM-derived metrics across 19 external cohorts. Why it matters: The development of GluFormer represents a significant advancement in personalized healthcare, enabling proactive and individualized health strategies through the analysis of dynamic glucose data.
This paper introduces an explainable machine learning framework for early-stage chronic kidney disease (CKD) screening, specifically designed for low-resource settings in Bangladesh and South Asia. The framework utilizes a community-based dataset from Bangladesh and evaluates multiple ML classifiers with feature selection techniques. Results show that the ML models achieve high accuracy and sensitivity, outperforming existing screening tools and demonstrating strong generalizability across independent datasets from India, the UAE, and Bangladesh.
MBZUAI Professor Agathe Guilloux developed the SigLasso model to forecast hospitalizations using real-time data from Google and Météo France during the COVID-19 pandemic. The model integrates mobility data and weather patterns to predict hospitalization rates 10-14 days in advance. SigLasso outperformed industry standards like GRU and Neural CDE in reducing reconstruction error. Why it matters: This research demonstrates the potential of AI to improve healthcare resource allocation and crisis management by accurately predicting patient flow using readily available data.
MBZUAI researchers developed FetalCLIP, an AI model trained on 210,000 ultrasound images for fast and reliable interpretation of fetal scans. MBZUAI's President Eric Xing contributed to the General Expression Transformer (GET), an AI foundation model acting as a biological simulator to predict gene behavior. MBZUAI and Carleton University created MedPromptX for quicker disease diagnosis and treatment plans using multimodal AI. Why it matters: These AI advancements from MBZUAI have the potential to revolutionize healthcare in the region and globally, from prenatal care to drug discovery and personalized medicine.
Søren Brunak presented deep learning approaches for analyzing disease trajectories using data from 7-10 million patients in Denmark and the USA. The models predict future outcomes like mortality and specific diagnoses, such as pancreatic cancer, using 15-40 years of patient data. Disease trajectories and explainable AI can generate hypotheses for molecular-level investigations into causal aspects of disease progression. Why it matters: This research demonstrates the potential of large-scale patient data and AI to improve disease prediction and generate hypotheses for further investigation into disease mechanisms relevant to regional healthcare systems.