MBZUAI's Kun Zhang is applying causal machine learning to improve drug development and precision medicine, focusing on answering 'why' questions. Traditional drug development is costly (est. $2B) due to extensive studies needed to determine drug toxicity and efficacy. Zhang is combining causal ML with organs-on-chips technology to improve pre-clinical drug testing, aiming to reduce the failure rate of drugs in human trials. Why it matters: By improving the accuracy of pre-clinical drug testing, this research could significantly reduce the cost and time required to bring new medicines to market in the region and worldwide.
This article discusses the use of artificial intelligence in precision oncology, particularly in understanding individual tumor mechanisms and aiding clinical decision-making. Dr. Xinghua Lu, with extensive experience in medicine and biomedical informatics, will present research on individualized Bayesian causal inference methods for investigating oncogenic mechanisms. These methods aim to provide clinical decision support at the cellular, tumor, and patient levels. Why it matters: AI-driven precision oncology can enable more personalized and effective cancer treatments, improving patient outcomes in the region and globally.
MBZUAI hosted a talk on causal AI, featuring Professor Jin Tian from Iowa State University. The talk covered enriching AI systems with causal reasoning capabilities, moving AI beyond prediction to understanding. Professor Tian shared research on causal inference and estimating causal effects from data, using a novel estimator with double/debiased machine learning (DML) properties. Why it matters: Causal AI can improve the explainability, robustness, and adaptability of AI systems, addressing limitations of purely statistical models.
Saber Salehkaleybar from EPFL presented a talk on causal discovery, focusing on learning causal relationships from observational data and through interventions. He discussed an approximation algorithm for experiment design under budget constraints, with applications in gene-regulatory networks. The talk also covered improvements to reduce the computational complexity of experiment design algorithms. Why it matters: Causal AI systems can lead to more intelligent decision-making in various fields.
MBZUAI researchers presented a new causal representation learning framework at ICLR for identifying latent causal variables in multimodal biological data. The framework addresses the challenge of uncovering underlying causal factors from lab tests, genetic information, and medical images. The new approach can identify latent causal variables and their influence on observed biological outcomes across modalities. Why it matters: The model's ability to analyze causal mechanisms between modalities can lead to more complete insights in biomedical research.