MBZUAI's Kun Zhang is applying causal machine learning to improve drug development and precision medicine, focusing on answering 'why' questions. Traditional drug development is costly (est. $2B) due to extensive studies needed to determine drug toxicity and efficacy. Zhang is combining causal ML with organs-on-chips technology to improve pre-clinical drug testing, aiming to reduce the failure rate of drugs in human trials. Why it matters: By improving the accuracy of pre-clinical drug testing, this research could significantly reduce the cost and time required to bring new medicines to market in the region and worldwide.
This article discusses the use of artificial intelligence in precision oncology, particularly in understanding individual tumor mechanisms and aiding clinical decision-making. Dr. Xinghua Lu, with extensive experience in medicine and biomedical informatics, will present research on individualized Bayesian causal inference methods for investigating oncogenic mechanisms. These methods aim to provide clinical decision support at the cellular, tumor, and patient levels. Why it matters: AI-driven precision oncology can enable more personalized and effective cancer treatments, improving patient outcomes in the region and globally.
MBZUAI Professor Kun Zhang is working on applying AI to understand cause-and-effect relationships in biology, with the goal of accelerating scientific discovery and improving human health. He aims to develop foundation models for biology that can process diverse data types and provide insights into the causes and treatments of health problems. These models could help scientists develop new medicines and preventative measures for diseases. Why it matters: This research has the potential to significantly advance the field of medicine by enabling a deeper understanding of the complex biological processes that underlie disease.
MBZUAI hosted a talk on causal AI, featuring Professor Jin Tian from Iowa State University. The talk covered enriching AI systems with causal reasoning capabilities, moving AI beyond prediction to understanding. Professor Tian shared research on causal inference and estimating causal effects from data, using a novel estimator with double/debiased machine learning (DML) properties. Why it matters: Causal AI can improve the explainability, robustness, and adaptability of AI systems, addressing limitations of purely statistical models.
Saber Salehkaleybar from EPFL presented a talk on causal discovery, focusing on learning causal relationships from observational data and through interventions. He discussed an approximation algorithm for experiment design under budget constraints, with applications in gene-regulatory networks. The talk also covered improvements to reduce the computational complexity of experiment design algorithms. Why it matters: Causal AI systems can lead to more intelligent decision-making in various fields.